APA
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Rezaee, M. E., Towe, M., Osman, M., Huynh, L., El-Khatib, F., Andrianne, R., … Yafi, F. (2020). A Multicenter Investigation Examining AUA-Recommended Antibiotic Prophylaxis vs. Non-standard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients. Journal of Urology.
Chicago/Turabian
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Rezaee, Michael E., M. Towe, M. Osman, L. Huynh, F. El-Khatib, R. Andrianne, G. Broderick, et al. “A Multicenter Investigation Examining AUA-Recommended Antibiotic Prophylaxis vs. Non-Standard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients.” Journal of Urology (2020).
MLA
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Rezaee, Michael E., et al. “A Multicenter Investigation Examining AUA-Recommended Antibiotic Prophylaxis vs. Non-Standard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients.” Journal of Urology, 2020.
BibTeX Click to copy
@article{michael2020a,
title = {A Multicenter Investigation Examining AUA-Recommended Antibiotic Prophylaxis vs. Non-standard Prophylaxis in Preventing Device Infections in Penile Prosthesis Surgery in Diabetic Patients.},
year = {2020},
journal = {Journal of Urology},
author = {Rezaee, Michael E. and Towe, M. and Osman, M. and Huynh, L. and El-Khatib, F. and Andrianne, R. and Broderick, G. and Burnett, A. and Gross, M. and Guise, A. and Hatzichristodoulou, G. and Henry, G. and Clavell-Hernández, J. and Hsieh, T. and Jenkins, L. and Lentz, A. and Munarriz, R. and Osmonov, D. and Park, S. and Perito, P. and Sadeghi-Nejad, H. and Sempels, M. and Simhan, J. and Wang, Run and Yafi, F.}
}
PURPOSE American Urological Association (AUA) antibiotic prophylaxis recommendations may be insufficient for covering organisms commonly found in penile prosthesis infections. The purpose of this study was to assess the difference between AUA-recommended antibiotic prophylaxis and non-standard prophylaxis in preventing device infections in penile prosthesis surgery performed in diabetics.
MATERIALS AND METHODS A multicenter, retrospective cohort study of diabetic patients undergoing primary penile prosthesis surgery was performed between April 2003 and August 2018. Eighteen institutions from the United States, Europe and Korea contributed. The association between antibiotic prophylaxis type and postoperative penile prosthesis infections, device explantations, and revision surgeries was assessed.
RESULTS Standard AUA antibiotic prophylaxis was followed in 48.6% (n=391) of cases, while non-standard prophylaxis was used in 51.4% (n=413). Common non-standard antibiotic prophylaxis included Vancomycin-Gentamycin- Fluoroquinolone, Clindamycin-Fluoroquinolone, and Vancomycin-Fluoroquinolone among other combinations. Patients who received AUA prophylaxis had significantly more postoperative device infections (5.6% vs. 1.9%, p<0.01) and explantations (8.3% vs. 2.0%, p<0.001) compared to those who received non-standard prophylaxis. Patients who received AUA prophylaxis had significantly higher odds of a postoperative device infection (OR: 2.8, 95% CI 1.1-7.3) and explantation (OR: 3.6, 95% CI 1.4-9.1) compared to those who received non-standard prophylaxis.
CONCLUSIONS Diabetic men with ED who received standard AUA prophylaxis for penile prosthesis surgery had significantly greater odds of experiencing a postoperative device infection and device explantation compared to patients who received non-standard prophylaxis. Our study provides a strong rationale for a prospective investigation to establish the most appropriate prophylaxis strategy in penile prosthesis surgery.